Effect of piperine on pentylenetetrazole induced seizures, cognition and oxidative stress in mice
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چکیده
منابع مشابه
Arsenic and Oxidative Stress in Pentylenetetrazole-induced Seizures in Mice
Background and Objective: Chronic arsenic toxicity is a widespread problem; the role of brain oxidative stress has been suggested in the genesis of epilepsy and in the post-seizure neuronal death. However, studies investigating the effects of arsenic on seizure and related mechanisms are limited. The purpose of this study was to examine the effect of prolonged exposure to sodium arsenite on oxi...
متن کاملPharmacological Studies on Khamira Marwarid: Effect on Pentylenetetrazole-Induced Seizures, Cognition and Biochemical Markers in Mice
Cognitive impairment in epileptics may be a consequence of the epileptogenic process as well as antiepileptic medication. Thus, there is need for drugs, which can suppress epileptogenesis as well as prevent cognitive impairment. In the present study, the effect of Khamira Marwarid (KAH 1 ), a formulation based on Indian system of Unani medicine, was evaluated on the course of pentylenetetrazole...
متن کاملpharmacological studies on khamira marwarid: effect on pentylenetetrazole-induced seizures, cognition and biochemical markers in mice
cognitive impairment in epileptics may be a consequence of the epileptogenic process as well as antiepileptic medication. thus, there is need for drugs, which can suppress epileptogenesis as well as prevent cognitive impairment. in the present study, the effect of khamira marwarid (kah 1 ), a formulation based on indian system of unani medicine, was evaluated on the course of pentylenetetrazole...
متن کاملEffect of Ocimum basilicum hydro-alcoholic extract on oxidative damage of brain tissue following seizures induced by pentylenetetrazole in mice
Introduction: A relationship between epileptic seizures and brain tissue oxidative damage has been suggested. Ocimum basilicum (O. basilicum) has been shown to have beneficial effects including hypnotic and protective against tissue oxidative damage. The present study was designed to evaluate the effects of O. basilicum hydro-alcoholic extract on oxidative damage of brain tissue following s...
متن کاملEvaluation of Anticonvulsant Effects of Nimodipine and Ascorbic Acid on Pentylenetetrazole- Induced Seizures in Mice
Introduction: The mechanisms underlying the vulnerability of the brain to seizures remains unknown. Calcium ions influx and oxidative stress have been implicated in a variety of acute and chronic epileptogenic conditions. The present study was aimed at investigating the effects of nimodipine and ascorbic acid (vitamin C) alone and in combination on pentylenetetrazole (PTZ) - induced seizures ...
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ژورنال
عنوان ژورنال: African Journal of Pharmacy and Pharmacology
سال: 2015
ISSN: 1996-0816
DOI: 10.5897/ajpp2013.3588